Why You Really Feel Hungover: 5 Biological Causes and How to Fix Them

You wake up groggy. Your head’s pounding. You’re nauseated, maybe shaky, and definitely regretting that third round.
But why does alcohol hit so hard the next day?

The answer isn’t random — it’s biological.
Here are the five main physiological reasons you feel awful after drinking, and what each one does to your body:


1. Dehydration

Alcohol is a diuretic, which means it tells your body to flush out fluids faster than normal. That leads to electrolyte losscellular dehydration, and all the classics:

  • Headache
  • Dry mouth
  • Dizziness

What to do: Start rehydrating with water plus electrolytes — like Liquid I.V., coconut water, or even just water with a pinch of salt and squeeze of lemon.

Young white male pouring a water bottle over him as he looks to hydrate himself.

2. Acetaldehyde Toxicity

When your liver breaks down alcohol, it converts it into a toxic compound called acetaldehyde — which is even worse for you than alcohol itself. If you drink faster than your liver can keep up, that chemical builds up in your system.

Symptoms include:

  • Nausea
  • Sweating
  • Elevated heart rate

What to do: Eat foods high in cysteine and antioxidants, like eggs, bananas, and green tea. Supplements like NAC or a B-complex can also support detox.

Young man in a gas mask to represent toxicity

3. Inflammation

Drinking alcohol triggers your immune system to release inflammatory cytokines — which can make you feel like you’re coming down with something.

Symptoms:

  • Body aches
  • Stiffness
  • Brain fog

What to do: Anti-inflammatory support helps. Think turmericomega-3s, or even light movement like a walk outside. A little ibuprofen may help, too (if your stomach tolerates it).

African American woman with hand on her back to show signs of pain and inflammation.

4. Low Blood Sugar

Your liver helps regulate blood glucose — but when it’s busy processing alcohol, blood sugar can crash. This leads to:

  • Shakiness
  • Intense cravings
  • Irritability or mood swings

What to do: Eat a balanced breakfast with protein + carbs. Avoid greasy junk food — try eggs and toast, oatmeal with nut butter, or a smoothie with fruit and protein powder.


5. Sleep Disruption

Even if you “slept for 8 hours,” alcohol disrupts REM sleep, the restorative phase of your sleep cycle. That’s why you can wake up feeling exhausted and mentally cloudy.

Symptoms:

  • Grogginess
  • Low energy
  • Persistent brain fog

What to do: Get sunlight early in the day and take a light walk to reset your circadian rhythm. A short 20-minute naplater on can help you feel more normal — but don’t overdo it. And yes, caffeine helps, but only after you’ve had water and food.

White woman falling asleep on her desk with books spread all over due to sleep deprivation.

Final Thoughts

Hangovers aren’t random punishment — they’re your body’s response to a chemical overload, sleep debt, and nutrient loss.
If you know the cause, you can start to treat the symptoms much more effectively.

Save this post for the next time you overdo it — and share it with someone who always says “I’m never drinking again” but probably will.

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